I try something yesterday :
At first I run an instance of zabbix_server
Then I create a new database called zabbix2 with some data and a new configuration file like this :
After I configure a frontend and run
zabbix_server -c /etc/zabbix/zabbix_server2.conf
And it seems to work well. Is there someone who try this before? Is there any known issues or bug? Advices are welcome.