Do I need to execute the optimize command? Do you guys do that? If so, how often?
https://dev.mysql.com/doc/refman/5.6...ize-table.html
https://dev.mysql.com/doc/refman/5.6...ize-table.html
10years history, is your DB at least partitioned ? if not your DB file will grow and grow and grow ( ibdata db file ) and youll soon run out of space, memory, zabbix will become slow, frontend unusable, no possibility to maintain DB, upgrades of zabbix will take long - update of DB schema >>>>> everybody will hate it 

and your db will grow and grow and grow .....unless it hits the housekeepr time and it will try to delete those things ( but if there will be to many items , history, etc it will not be able to keep with the speed of growth - thats why people are advised to use partitioning - than you just drop partitions older than 1 month for example - you dont need to do it via selects in DB - its faster and more effective than housekeeper ) 
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