Look at this set of actions. After multiple messages to MySQL administrators and escalation to the manager, Zabbix will try to restart the MySQL database. It will happen if problem exists for 2:30 hours and it hasn't been acknowledged.
If the problems still exists, after another 30 minutes Zabbix will send a message to all users in Japan.
If this does help, after another hour Zabbix will reboot server with the MySQL database (second remote command) using IPMI commands.